Neuronal Oxidative Stress Promotes α-Synuclein Aggregation In Vivo

• Main Authors: Seok Joon Won (Author), Rebecca Fong (Author), Nicholas Butler (Author), Jennifer Sanchez (Author), Yiguan Zhang (Author), Candance Wong (Author), Olive Tambou Nzoutchoum (Author), Annie Huynh (Author), June Pan (Author), Raymond A. Swanson (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Both genetic and environmental factors increase risk for Parkinson's disease. Many of the known genetic factors influence α-synuclein aggregation or degradation, whereas most of the identified environmental factors produce oxidative stress. Studies using in vitro approaches have identified mech...