Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population

• Main Authors: Eiji Hishinuma (Author), Yoko Narita (Author), Kai Obuchi (Author), Akiko Ueda (Author), Sakae Saito (Author), Shu Tadaka (Author), Kengo Kinoshita (Author), Masamitsu Maekawa (Author), Nariyasu Mano (Author), Noriyasu Hirasawa (Author), Masahiro Hiratsuka (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene, is the rate-limiting enzyme in 5-fluorouracil (5-FU) degradation. In Caucasians, four DPYD risk variants are recognized to be responsible for interindividual variations in the development of 5-FU toxicity. However, these risk variants...