Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways

• Main Authors: Hany H. Arab (Author), Ebtehal Mohammad Fikry (Author), Shuruq E. Alsufyani (Author), Ahmed M. Ashour (Author), Azza A. K. El-Sheikh (Author), Hany W. Darwish (Author), Abdullah M. Al-Hossaini (Author), Muhammed A. Saad (Author), Muhammad Y. Al-Shorbagy (Author), Ahmed H. Eid (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable antioxidant and anti-apoptotic features. It has shown marked cardio-, reno-, hepato-, and neuroprotective effects. Yet, its e...