Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways

• 主要な著者: Hany H. Arab (著者), Ebtehal Mohammad Fikry (著者), Shuruq E. Alsufyani (著者), Ahmed M. Ashour (著者), Azza A. K. El-Sheikh (著者), Hany W. Darwish (著者), Abdullah M. Al-Hossaini (著者), Muhammed A. Saad (著者), Muhammad Y. Al-Shorbagy (著者), Ahmed H. Eid (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2 inhibitor with notable antioxidant and anti-apoptotic features. It has shown marked cardio-, reno-, hepato-, and neuroprotective effects. Yet, its e...