Overexpression of estrogen receptor β inhibits cellular functions of human hepatic stellate cells and promotes the anti-fibrosis effect of calycosin via inhibiting STAT3 phosphorylation

• Glavni autori: Yaxin Wang (Autor), Canyan Wu (Autor), Jiahui Zhou (Autor), Haiming Fang (Autor), Jiajia Wang (Autor)
• Format: Knjiga
• Izdano: BMC, 2022-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Estrogen receptor β (ERβ) is the major ER subtype in hepatic stellate cells (HSCs). Previously we reported phytoestrogen calycosin suppressed liver fibrosis progression and inhibited HSC-T6 cell functions, suggesting the effects may be related to ERβ. Here, we explore the effect...