From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19

From gene to dose: Long-read sequencing and *-allele tools to refine phenotype predictions of CYP2C19

Background: Inter-individual differences in drug response based on genetic variations can lead to drug toxicity and treatment inefficacy. A large part of this variability is caused by genetic variants in pharmacogenes. Unfortunately, the Single Nucleotide Variant arrays currently used in clinical ph...

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Main Authors: Lonneke J. Graansma (Author), Qinglian Zhai (Author), Loes Busscher (Author), Roberta Menafra (Author), Redmar R. van den Berg (Author), Susan L. Kloet (Author), Maaike van der Lee (Author)
Format: Book
Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
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3rd Floor Main Library

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