An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups

• Autores principales: Hualong Lin (Autor), Mingyang Yang (Autor), Cong Li (Autor), Bolong Lin (Autor), Xianming Deng (Autor), Hongbin He (Autor), Rongbin Zhou (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

NLRP3 inflammasome is involved in the pathology of multiple human inflammatory diseases but there are still no clinically available medications targeting the NLRP3 inflammasome. We have previously identified RRx-001 as a highly selective and potent NLRP3 inhibitor, however, it contains high-energy n...