Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species.

• Main Authors: Jéssica Cristina Dos Santos (Author), Bas Heinhuis (Author), Rodrigo Saar Gomes (Author), Michelle S M A Damen (Author), Fernando Real (Author), Renato A Mortara (Author), Samuel T Keating (Author), Charles A Dinarello (Author), Leo A B Joosten (Author), Fátima Ribeiro-Dias (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Interleukin-32 (IL-32) is expressed in lesions of patients with American Tegumentary Leishmaniasis (ATL), but its precise role in the disease remains unknown. METHODOLOGY/PRINCIPAL FINDINGS:In the present study, silencing and overexpression of IL-32 was performed in THP-1-derived macropha...