Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs
New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds <b>6b</b> and <b>6j</b> showed higher in vitro COX-2 selectivity and inhibitory activity (IC<sub>50</sub> = 0.0...
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स्वरूप: | पुस्तक |
प्रकाशित: |
MDPI AG,
2022-09-01T00:00:00Z.
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A1234.567 |
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प्रति 1 | उपलब्ध |