Rational Design and Synthesis of New Selective COX-2 Inhibitors with In Vivo PGE2-Lowering Activity by Tethering Benzenesulfonamide and 1,2,3-Triazole Pharmacophores to Some NSAIDs

• Main Authors: Nada H. El-Dershaby (Author), Soad A. El-Hawash (Author), Shaymaa E. Kassab (Author), Hoda G. Daabees (Author), Ahmed E. Abdel Moneim (Author), Mostafa M. M. El-Miligy (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

New selective COX-2 inhibitors were designed and synthesized by tethering 1,2,3-triazole and benzenesulfonamide pharmacophores to some NSAIDs. Compounds <b>6b</b> and <b>6j</b> showed higher in vitro COX-2 selectivity and inhibitory activity (IC₅₀ = 0.0...