Is Dosing of Ethambutol as Part of a Fixed-Dose Combination Product Optimal for Mechanically Ventilated ICU Patients with Tuberculosis? A Population Pharmacokinetic Study

• Main Authors: Francisco Beraldi-Magalhaes (Author), Suzanne L. Parker (Author), Cristina Sanches (Author), Leandro Sousa Garcia (Author), Brenda Karoline Souza Carvalho (Author), Mariana Millan Fachi (Author), Marcus Vinicius de Liz (Author), Roberto Pontarolo (Author), Jeffrey Lipman (Author), Marcelo Cordeiro-Santos (Author), Jason A. Roberts (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tuberculosis (TB) patients admitted to intensive care units (ICU) have high mortality rates. It is uncertain whether the pharmacokinetics of first-line TB drugs in ICU patients are different from outpatients. This study aims to compare the pharmacokinetics of oral ethambutol in TB patien...