Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation

• Autors principals: Tayyaba Afsar (Autor), Suhail Razak (Autor), Janeen H. Trembley (Autor), Khushbukhat Khan (Autor), Maria Shabbir (Autor), Ali Almajwal (Autor), Nawaf W. Alruwaili (Autor), Muhammad Umar Ijaz (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Cis-diamminedichloroplatinum (II) (CDDP) is a widely used antineoplastic agent with numerous associated side effects. We investigated the mechanisms of action of the indole derivative N'-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2-methyl-1H-inden-3-yl) acetohydr...