Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model

• Main Authors: Tommaso Vannocci (Author), Roberto Notario Manzano (Author), Ombretta Beccalli (Author), Barbara Bettegazzi (Author), Fabio Grohovaz (Author), Gianfelice Cinque (Author), Antonio de Riso (Author), Luca Quaroni (Author), Franca Codazzi (Author), Annalisa Pastore (Author)
• Format: Book
• Published: The Company of Biologists, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The neurodegenerative disease Friedreich's ataxia is caused by lower than normal levels of frataxin, an important protein involved in iron-sulfur (Fe-S) cluster biogenesis. An important step in designing strategies to treat this disease is to understand whether increasing the frataxin levels by...