Sinapic acid alleviates 5-fluorouracil-induced nephrotoxicity in rats via Nrf2/HO-1 signalling

• Main Authors: Mushtaq Ahmad Ansari (Author), Mudassar Shahid (Author), Sheikh F. Ahmad (Author), Ajaz Ahmad (Author), Abdulrazaq Alanazi (Author), Abdul Malik (Author), Yousef A. Bin Jardan (Author), Sabry M. Attia (Author), Saleh A. Bakheet (Author), Mohammad Raish (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fluoropyrimidine 5-fluorouracil (5-FU) is a DNA analogue broadly used in chemotherapy, though treatment-associated nephrotoxicity limits its widespread clinical use. Sinapic acid (SA) has potent antioxidant, anti-inflammatory, and anti-apoptotic effects, we investigated its protective effects agains...