Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

• Main Authors: Jianmei Yang (Author), Enli Wang (Author), Mingmin Jiang (Author), Yujun Tan (Author), Fangfang Yao (Author), Chenghong Sun (Author), Lihong Pan (Author), Ling Gao (Author), Jingchun Yao (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS...