NEURODEGENERATION CAUSED BY TRIMETHYLTIN VIA INHIBITION OF TROPOMYOSIN-RECEPTOR-KINASE B AND PHOSPHOINOSITIDE 3-KINASE/PROTEIN KINASE B SIGNALING CASCADE

• Main Authors: Tran Phi Hoang Yen (Author), Nguyen Ngoc Khoi (Author), Duong Phuoc An (Author), Nguyen Thi Thu Van (Author), Do Minh Quang (Author)
• Format: Book
• Published: Universitas Gadjah Mada, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/B phosphorylation on Tyr490/Tyr516 of TMTtreated...