Caspase Inhibition Augmented Oridonin-Induced Cell Death in Murine Fibrosarcoma L 929 by Enhancing Reactive Oxygen Species Generation

• Main Authors: Jin-Nan Wu (Author), Jian Huang (Author), Jia Yang (Author), Shin-Ichi Tashiro (Author), Satoshi Onodera (Author), Takashi Ikejima (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oridonin, a diterpenoid isolated from Rabdosia rubescences, has been reported to have antitumor effects. In this study, the growth-inhibitory activity of oridonin for L929 cells was exerted in a time-and dose-dependent manner. After treatment with oridonin for 24 h, L929 cells underwent both apoptos...