Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery

• Main Authors: Chris Kato (Author), Koji Ueda (Author), Satoru Morimoto (Author), Shinichi Takahashi (Author), Shiho Nakamura (Author), Fumiko Ozawa (Author), Daisuke Ito (Author), Yugaku Daté (Author), Kensuke Okada (Author), Naoki Kobayashi (Author), Jin Nakahara (Author), Hideyuki Okano (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers. Notably, the comparative and longitudinal alterations in the protein profiles of EVs in serum (sEVs) and cerebrospinal fluid (CSF; cEVs...