Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

Antagonizing Arachidonic Acid-Derived Eicosanoids Reduces Inflammatory Th17 and Th1 Cell-Mediated Inflammation and Colitis Severity

During colitis, activation of two inflammatory T cell subsets, Th17 and Th1 cells, promotes ongoing intestinal inflammatory responses. n-6 polyunsaturated fatty acid- (PUFA-) derived eicosanoids, such as prostaglandin E2 (PGE2), promote Th17 cell-mediated inflammation, while n-3 PUFA antagonize both...

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Main Authors: Jennifer M. Monk (Author), Harmony F. Turk (Author), Yang-Yi Fan (Author), Evelyn Callaway (Author), Brad Weeks (Author), Peiying Yang (Author), David N. McMurray (Author), Robert S. Chapkin (Author)
Format: Book
Published: Hindawi Limited, 2014-01-01T00:00:00Z.
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3rd Floor Main Library

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