High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

• Главные авторы: Hai-Quyen Tran (Автор), Yoon Hee Chung (Автор), Eun-Joo Shin (Автор), Won Ki Kim (Автор), Jae-Chul Lee (Автор), Ji Hoon Jeong (Автор), Myung Bok Wie (Автор), Choon-Gon Jang (Автор), Kiyofumi Yamada (Автор), Toshitaka Nabeshima (Автор), Hyoung-Chun Kim (Автор)
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• Опубликовано: Elsevier, 2016-10-01T00:00:00Z.
• Предметы: article
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Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses....