High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

• Main Authors: Hai-Quyen Tran (Author), Yoon Hee Chung (Author), Eun-Joo Shin (Author), Won Ki Kim (Author), Jae-Chul Lee (Author), Ji Hoon Jeong (Author), Myung Bok Wie (Author), Choon-Gon Jang (Author), Kiyofumi Yamada (Author), Toshitaka Nabeshima (Author), Hyoung-Chun Kim (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses....