Tacaribe virus but not junin virus infection induces cytokine release from primary human monocytes and macrophages.

• Main Authors: Allison Groseth (Author), Thomas Hoenen (Author), Michaela Weber (Author), Svenja Wolff (Author), Astrid Herwig (Author), Andreas Kaufmann (Author), Stephan Becker (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanisms underlying the development of disease during arenavirus infection are poorly understood. However, common to all hemorrhagic fever diseases is the involvement of macrophages as primary target cells, suggesting that the immune response in these cells may be of paramount importance durin...