EZH2-Mediated Epigenetic Suppression of GDF15 Predicts a Poor Prognosis and Regulates Cell Proliferation in Non-Small-Cell Lung Cancer

• Main Authors: Xiyi Lu (Author), Xuezhi He (Author), Jun Su (Author), Jing Wang (Author), Xinyin Liu (Author), Kun Xu (Author), Wei De (Author), Erbao Zhang (Author), Renhua Guo (Author), Yuenian Eric Shi (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Growth differentiation factor 15 (GDF15), a member of the TGF-β superfamily of cytokines, has been reported to exert very heterogeneous functions in various tumors. However, its expression and roles in mediating non-small-cell lung cancer (NSCLC) progression remain unknown. In this study, we found t...