The use of extrapolation based on modeling and simulation to support high‐dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft‐tissue infections

• 主要な著者: Phylinda L.S. Chan (著者), Lynn McFadyen (著者), Andrea Quaye (著者), Heidi Leister‐Tebbe (著者), Victoria M. Hendrick (著者), Jennifer Hammond (著者), Susan Raber (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2021-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract A model‐informed drug development approach was used to select ceftaroline fosamil high‐dose regimens for pediatric patients with complicated skin and soft‐tissue infections caused by Staphylococcus aureus with a ceftaroline minimum inhibitory concentration (MIC) of 2 or 4 mg/L. Steady‐state...