Total saponins of Bolbostemma paniculatum (maxim.) Franquet exert antitumor activity against MDA-MB-231 human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway

• Main Authors: Jian-Wei Dou (Author), Rong-Guo Shang (Author), Xiao-Qin Lei (Author), Kang-Le Li (Author), Zhan-Zi Guo (Author), Kai Ye (Author), Xiao-Juan Yang (Author), Yu-Wei Li (Author), Yun-Yun Zhou (Author), Jia Yao (Author), Qian Huang (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The aim of the present study was to examine the effects of the Bolbostemma paniculatum (Maxim.) Franquet (BP) active compound, BP total saponins (BPTS), on MDA-MB-231 cells, and investigate the underlying mechanism regarding BPTS-mediated attenuation of the PI3K/Akt/mTOR pathway....