Development, Characterization, and In Vivo Evaluation of a Novel Aptamer (Anti-MUC1/Y) for Breast Cancer Therapy

• Main Authors: Huma Khan (Author), Vaidehi Makwana (Author), Sofia Nascimento dos Santos (Author), Carlos Eduardo Bonacossa de Almeida (Author), Ralph Santos-Oliveira (Author), Sotiris Missailidis (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by...