Population Pharmacokinetic Analysis for Imipenem-Relebactam in Healthy Volunteers and Patients With Bacterial Infections

• Главные авторы: Pratik Bhagunde (Автор), Parul Patel (Автор), Mallika Lala (Автор), Kenny Watson (Автор), William Copalu (Автор), Ming Xu (Автор), Pooja Kulkarni (Автор), Katherine Young (Автор), Matthew L. Rizk (Автор)
• Формат: ‌
• Опубликовано: Wiley, 2019-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Relebactam is a small‐molecule β‐lactamase inhibitor developed as a fixed‐dose combination with imipenem/cilastatin. The pharmacokinetics of relebactam and imipenem across 10 clinical studies were analyzed using data from adult healthy volunteers and patients with bacterial infections. Renal functio...