Application of Sucrose Acetate Isobutyrate in Development of Co-Amorphous Formulations of Tacrolimus for Bioavailability Enhancement

• Main Authors: Eman M. Mohamed (Author), Sathish Dharani (Author), Mohammad T. H. Nutan (Author), Phillip Cook (Author), Rajendran Arunagiri (Author), Mansoor A. Khan (Author), Ziyaur Rahman (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The focus of the present work was to develop co-amorphous dispersion (CAD) formulations of tacrolimus (TAC) using sucrose acetate isobutyrate as a carrier, evaluate by in vitro and in vivo methods and compare its performance with hydroxypropyl methylcellulose (HPMC) based amorphous solid dispersion...