The potential role of RNA sequencing in diagnosing unexplained insensitivity to conventional chemotherapy in pediatric patients with B-cell acute lymphoblastic leukemia

• Main Authors: Xinyu Li (Author), Zaoli Huang (Author), Liwen Zhu (Author), Weixin Lai (Author), Yunyao Li (Author), Han Chen (Author), Diandian Liu (Author), Junjiu Huang (Author), Dunhua Zhou (Author), Yang Li (Author), Wenjun Weng (Author), Honggui Xu (Author), Luhong Xu (Author), Zhenhua Luo (Author), Jianpei Fang (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pediatric B-cell acute lymphoblastic leukemia (B-ALL) is a highly heterogeneous disease. According to large-scale RNA sequencing (RNA-seq) data, B-ALL patients can be divided into more than 10 subgroups. However, many genomic defects associated with resistance mechanisms have not yet been i...