Multi-omics analysis to reveal the synergistic mechanism underlying the multiple ingredients of Stephania tetrandra extract on rheumatoid arthritis through the PI3K/Akt signaling pathway

• Main Authors: Jinfeng Chen (Author), An Zhang (Author), Anzheng Nie (Author), Xiaoxiao Zuo (Author), Lei Zhang (Author), Yuxue Jiao (Author), Lulu Wang (Author), Yang Yang (Author), Kun Liu (Author), Xinli Xue (Author), Yuanyuan Zhuang (Author), Yansha Meng (Author), Jing-Hua Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background:Stephania tetrandra has been used for treating rheumatic diseases for thousands of years in rural areas of China. Several studies have found that tetrandrine and fangchinoline can inactivate the PI3K/Akt signaling pathway by reducing the expression and phosphorylation of AKT. However, the...