Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6‐Mediated Metabolic Activity

• मुख्य लेखकों: Rachel Dalton (लेखक), Seung‐been Lee (लेखक), Katrina G. Claw (लेखक), Bhagwat Prasad (लेखक), Brian R. Phillips (लेखक), Danny D. Shen (लेखक), Lai Hong Wong (लेखक), Mitch Fade (लेखक), Matthew G. McDonald (लेखक), Maitreya J. Dunham (लेखक), Douglas M. Fowler (लेखक), Allan E. Rettie (लेखक), Erin Schuetz (लेखक), Timothy A. Thornton (लेखक), Deborah A. Nickerson (लेखक), Andrea Gaedigk (लेखक), Kenneth E. Thummel (लेखक), Erica L. Woodahl (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2020-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved when diplotype assignments incorporate structural var...