Systematic Evaluation of Voriconazole Pharmacokinetic Models without Pharmacogenetic Information for Bayesian Forecasting in Critically Ill Patients

• Main Authors: Simon Kallee (Author), Christina Scharf (Author), Lea Marie Schatz (Author), Michael Paal (Author), Michael Vogeser (Author), Michael Irlbeck (Author), Johannes Zander (Author), Michael Zoller (Author), Uwe Liebchen (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Voriconazole (VRC) is used as first line antifungal agent against invasive aspergillosis. Model-based approaches might optimize VRC therapy. This study aimed to investigate the predictive performance of pharmacokinetic models of VRC without pharmacogenetic information for their suitability for model...