Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif.

• Main Authors: Issa Abu-Dayyeh (Author), Marina Tiemi Shio (Author), Shintaro Sato (Author), Shizuo Akira (Author), Benoit Cousineau (Author), Martin Olivier (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasites of the Leishmania genus can rapidly alter several macrophage (MØ) signalling pathways in order to tame down the innate immune response and inflammation, therefore favouring their survival and propagation within their mammalian host. Having recently reported that Leishmania and bacterial LP...