MYC amplifications are common events in childhood osteosarcoma

• Main Authors: Solange De Noon (Author), Jannat Ijaz (Author), Tim HH Coorens (Author), Fernanda Amary (Author), Hongtao Ye (Author), Anna Strobl (Author), Iben Lyskjær (Author), Adrienne M Flanagan (Author), Sam Behjati (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Osteosarcoma, the most common primary malignant tumour of bone, affects both children and adults. No fundamental biological differences between paediatric and adult osteosarcoma are known. Here, we apply multi‐region whole‐genome sequencing to an index case of a 4‐year‐old child whose aggre...