Long-Term Survival and Induction of Operational Tolerance to Murine Islet Allografts by Co-Transplanting Cyclosporine A Microparticles and CTLA4-Ig

• Main Authors: Purushothaman Kuppan (Author), Jordan Wong (Author), Sandra Kelly (Author), Jiaxin Lin (Author), Jessica Worton (Author), Chelsea Castro (Author), Joy Paramor (Author), Karen Seeberger (Author), Nerea Cuesta-Gomez (Author), Colin C. Anderson (Author), Gregory S. Korbutt (Author), Andrew R. Pepper (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

One strategy to prevent islet rejection is to create a favorable immune-protective local environment at the transplant site. Herein, we utilize localized cyclosporine A (CsA) delivery to islet grafts via poly(lactic-co-glycolic acid) (PLGA) microparticles to attenuate allograft rejection. CsA-elutin...