Guidance on Selecting Optimal Steady-State Tacrolimus Concentrations for Continuous IV Perfusion: Insights from Physiologically Based Pharmacokinetic Modeling

• Main Authors: Romain Martischang (Author), Argyro Nikolaou (Author), Youssef Daali (Author), Caroline Flora Samer (Author), Jean Terrier (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2024-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

<b>Introduction</b>: The dose-response relationships of tacrolimus have been primarily assessed through trough concentrations during intermittent administrations. In scenarios where oral administration (PO) is unfeasible, continuous intravenous (IV) administration is advised. Under these...