Guidance on Selecting Optimal Steady-State Tacrolimus Concentrations for Continuous IV Perfusion: Insights from Physiologically Based Pharmacokinetic Modeling

• Những tác giả chính: Romain Martischang (Tác giả), Argyro Nikolaou (Tác giả), Youssef Daali (Tác giả), Caroline Flora Samer (Tác giả), Jean Terrier (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2024-08-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

<b>Introduction</b>: The dose-response relationships of tacrolimus have been primarily assessed through trough concentrations during intermittent administrations. In scenarios where oral administration (PO) is unfeasible, continuous intravenous (IV) administration is advised. Under these...