Synthesis and Evaluation of Novel ⁶⁸Ga-Labeled [D-Phe⁶,Leu¹³ψThz¹⁴]bombesin(6-14) Analogs for Cancer Imaging with Positron Emission Tomography

• Main Authors: Lei Wang (Author), Chao-Cheng Chen (Author), Zhengxing Zhang (Author), Hsiou-Ting Kuo (Author), Chengcheng Zhang (Author), Nadine Colpo (Author), Helen Merkens (Author), François Bénard (Author), Kuo-Shyan Lin (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastrin-releasing peptide receptor (GRPR) is overexpressed in various cancers and is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake and/or metabolic instability observed for most reported GRPR-targeted radioligands might limit their clinical applications. Our...