Synthesis of pyrazole and pyrazoline derivatives of β-ionone: Exploring anti-inflammatory potential, cytotoxicity, and molecular docking insights

• Main Authors: Monika Sihag (Author), Anju Manuja (Author), Swati Rani (Author), Rinku Soni (Author), Neha Rani (Author), Sandeep Malik (Author), Kirti Bhardwaj (Author), Balvinder Kumar (Author), Mayank Kinger (Author), Monika Miglani (Author), Deepak Kumar Aneja (Author)
• Format: Book
• Published: Elsevier, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present paper, pyrazole and pyrazoline derivatives of β-ionone were synthesized. The protocol involved intramolecular oxidative C-H amination of hydrazone to yield corresponding pyrazole in moderate to good yields. Another methodology comprising of condensation of hydrazine hydrochloride with...