Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51

• Main Authors: Fuqiang Chen (Author), Wenna Zhao (Author), Chenghong Du (Author), Zihan Chen (Author), Jie Du (Author), Meijuan Zhou (Author)
• Format: Book
• Published: BMC, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a key factor in the development of lung pathology. Understanding the mech...