The Role of IL-36 in the Pathophysiological Processes of Autoimmune Diseases

• Main Authors: Wen-jian Chen (Author), Xiao Yu (Author), Xin-Rong Yuan (Author), Bang-jie Chen (Author), Na Cai (Author), Shuo Zeng (Author), Yuan-song Sun (Author), Hai-wen Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A member of the interleukin (IL)-1 superfamily was IL-36, which contained IL-36α, IL-36β, IL-36γ, and IL-36Ra. Heterotrimer complexes, consisting of heterodimeric receptor complexes and IL-36 agonist, gave signals through intracellular functional domains, so as to bind to downstream proteins and ind...