Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine

• Main Authors: Ioana Alesutan (Author), Katharina Musculus (Author), Tatsiana Castor (Author), Kousi Alzoubi (Author), Jakob Voelkl (Author), Florian Lang (Author)
• Format: Book
• Published: Karger Publishers, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Excessive phosphate concentrations trigger vascular calcification, an active process promoted by osteoinduction of vascular smooth muscle cells (VSMCs) with increased expression and activity of transcription factor RUNX2 (Core-binding factor α1, CBFA1), alkaline phosphatase (ALPL),...