Design, synthesis, and cytotoxicity evaluation of novel indole-acylhydrazone derivatives of 4-pyridinone as potential histone deacetylase-2 inhibitors

• Main Authors: Niloofar Naghi-Ganji (Author), Lotfollah Saghaei (Author), Farial Tavakoli (Author), Vajihe Azimian (Author), Mina Mirian (Author), Hajar Sirous (Author), Mahboubeh Rostami (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: Histone deacetylation is one of the essential cellular pathways in the growth and spread of cancer, so the design of histone deacetylase (HDAC) inhibitors as anticancer agents is of great importance in pharmaceutical chemistry. Here, a series of indole acylhydrazone derivativ...