Reducing agents facilitate membrane patch seal integrity and longevity

• Main Authors: Damayantee Das (Author), Anson Wong (Author), Timothy N. Friedman (Author), Bradley J Kerr (Author), Harley T. Kurata (Author), Shawn M. Lamothe (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but can be challenging due to variables including operator...