Sultiame pharmacokinetic profile in plasma and erythrocytes after single oral doses: A pilot study in healthy volunteers

• Principais autores: Kim Dao (Autor), Paul Thoueille (Autor), Laurent A. Decosterd (Autor), Thomas Mercier (Autor), Monia Guidi (Autor), Carine Bardinet (Autor), Sébastien Lebon (Autor), Eva Choong (Autor), Arnaud Castang (Autor), Catherine Guittet (Autor), Luc‐André Granier (Autor), Thierry Buclin (Autor)
• Formato: Livro
• Publicado em: Wiley, 2020-02-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract A pilot study was conducted aiming at specifying sultiame's pharmacokinetic profile, completed by in vitro assays evaluating the intraerythrocytic transfer of sultiame and by a pharmacokinetic model assessing its distribution. Single oral doses of sultiame (Ospolot® 50, 100, and 200 mg...