Getting the dose right using physiologically-based pharmacokinetic modeling: dexamethasone to prevent post-extubation stridor in children as proof of concept

• Main Authors: Joyce E. M. van der Heijden (Author), Marika de Hoop-Sommen (Author), Noa Hoevenaars (Author), Jolien J. M. Freriksen (Author), Koen Joosten (Author), Rick Greupink (Author), Saskia N. de Wildt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionCritically ill patients show large variability in drug disposition due to e.g., age, size, disease and treatment modalities. Physiologically-based pharmacokinetic (PBPK) models can be used to design individualized dosing regimens taking this into account. Dexamethasone, prescribed for th...