The Effect of Intracellular Tacrolimus Exposure on Calcineurin Inhibition in Immediate- and Extended-Release Tacrolimus Formulations

• Main Authors: Pere Fontova (Author), Lisanne N. van Merendonk (Author), Anna Vidal-Alabró (Author), Raül Rigo-Bonnin (Author), Gema Cerezo (Author), Stefaan van Oevelen (Author), Oriol Bestard (Author), Edoardo Melilli (Author), Nuria Montero (Author), Ana Coloma (Author), Anna Manonelles (Author), Joan Torras (Author), Josep M. Cruzado (Author), Josep M. Grinyó (Author), Helena Colom (Author), Nuria Lloberas (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy. Intracellular tacrolimus concentrations could better reflect exposure at the site of action and its pharmacodynamics (PD). Intracellular pharmacokinet...