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The Effect of Intracellular Tacrolimus Exposure on Calcineurin Inhibition in Immediate- and Extended-Release Tacrolimus Formulations

Despite intensive monitoring of whole blood tacrolimus concentrations, acute rejection after kidney transplantation occurs during tacrolimus therapy. Intracellular tacrolimus concentrations could better reflect exposure at the site of action and its pharmacodynamics (PD). Intracellular pharmacokinet...

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Main Authors: Pere Fontova (Author), Lisanne N. van Merendonk (Author), Anna Vidal-Alabró (Author), Raül Rigo-Bonnin (Author), Gema Cerezo (Author), Stefaan van Oevelen (Author), Oriol Bestard (Author), Edoardo Melilli (Author), Nuria Montero (Author), Ana Coloma (Author), Anna Manonelles (Author), Joan Torras (Author), Josep M. Cruzado (Author), Josep M. Grinyó (Author), Helena Colom (Author), Nuria Lloberas (Author)
Format: Book
Published: MDPI AG, 2023-05-01T00:00:00Z.
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