The extended clearance model and its use for the interpretation of hepatobiliary elimination data

• Main Authors: Gian Camenisch (Author), Julia Riede (Author), Annett Kunze (Author), Jörg Huwyler (Author), Birk Poller (Author), Kenichi Umehara (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatic elimination is a function of the interplay between different processes such as sinusoidal uptake, intracellular metabolism, canalicular (biliary) secretion, and sinusoidal efflux. In this review, we outline how drugs can be classified according to their in vitro determined clearance mechanis...