Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression and decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages as compared to other opiates in clinical trials, possibly du...

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Main Authors: Liang Ye (Author), Chunmei Li (Author), Wanglin Jiang (Author), Yifei Yang (Author), Wenyan Wang (Author), Haibo Zhu (Author), Zhengping Hu (Author), Ning Li (Author), Xiaobo Cen (Author), Hongbo Wang (Author), Jingwei Tian (Author)
Format: Book
Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
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