Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist
Opiates produce analgesia via G-protein signaling, and adverse effects, such as respiratory depression and decreased bowel motility, by β-arrestin pathway. Oliceridine, a G protein-biased MOR agonist, only presents modest safety advantages as compared to other opiates in clinical trials, possibly du...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2023-08-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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