Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene

• Main Authors: Valentina Vengeliene (Author), Anton Bespalov (Author), Martin Roßmanith (Author), Sandra Horschitz (Author), Stefan Berger (Author), Ana L. Relo (Author), Hamid R. Noori (Author), Peggy Schneider (Author), Thomas Enkel (Author), Dusan Bartsch (Author), Miriam Schneider (Author), Berthold Behl (Author), Anita C. Hansson (Author), Patrick Schloss (Author), Rainer Spanagel (Author)
• Format: Book
• Published: The Company of Biologists, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The research domain criteria (RDoC) matrix has been developed to reorient psychiatric research towards measurable behavioral dimensions and underlying mechanisms. Here, we used a new genetic rat model with a loss-of-function point mutation in the dopamine transporter (DAT) gene (Slc6a3_N157K) to sys...