Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogues of mexiletine

• Main Authors: Jean-François eDesaphy (Author), Antonella eDipalma (Author), Teresa eCostanza (Author), Roberta eCarbonara (Author), Maria Maddalena eDinardo (Author), Alessia eCatalano (Author), Alessia eCarocci (Author), Giovanni eLentini (Author), Carlo eFranchini (Author), Diana eConte Camerino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously showed that the β-adrenoceptor modulators, clenbuterol and propranolol, directly blocked voltage-gated sodium channels, whereas salbutamol and nadolol did not (Desaphy et al., 2003), suggesting the presence of two hydroxyl groups on the aromatic moiety of the drugs as a molecular requi...